There’s been much speculation about what was in that “glowing briefcase.”
There are several esoteric theories, such as Ark of the Covenant, Marcellus’ soul, and pure evil.
There was also a lot of mundane speculation about, gold bricks, glow rocks and Tunguska soil.
My favorite theory is that it was the diamonds from Reservoir Dogs. I like the tangled connectivity.
Catherine Fuchs' Wholebody Wellness 
The last theory really struck me as a fantastic creative device. I think if I had to believe one of the myriad possiblities, it would be first on my list for the aesthetic simplicity. However, for most vague plot elements, metaphors and symbolism in works of fiction I tend to lean towards open interpretation, unless of course the meaning is fairly straightforward or is meant to be deciphered. Open interpretation creates a personal bond with the story that is unique to the individual, and also serves to add mystique to the story universe; mystique that some mistake for plot holes in need of filling. Over analysis has a tendency to sometimes ruin a good thing, or make something artistic or visionary turn into misconception or tedious dissection (don’t get me wrong, I do enjoy unravelling a good mystery and picking apart even the most complex plot). On the other hand, nothing starts a conversation like differing opinions on popular film and literature 🙂
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